Molecular characterization of HIV type 1 isolates from untreated patients of Mumbai (Bombay), India, and detection of rare resistance mutations

Alaka Deshpande; Patricia Recordon-Pinson; Ranjana Deshmukh; Muriel Faure; Valérie Jauvin; Isabelle Garrigue; Marie-Edith Lafon; Hervé J Fleury

doi:10.1089/aid.2004.20.1032

Molecular characterization of HIV type 1 isolates from untreated patients of Mumbai (Bombay), India, and detection of rare resistance mutations

AIDS Res Hum Retroviruses. 2004 Sep;20(9):1032-5. doi: 10.1089/aid.2004.20.1032.

Authors

Alaka Deshpande¹, Patricia Recordon-Pinson, Ranjana Deshmukh, Muriel Faure, Valérie Jauvin, Isabelle Garrigue, Marie-Edith Lafon, Hervé J Fleury

Affiliation

¹ Grant Medical College and Sir JJ Hospital, Byculla, Mumbai, India.

PMID: 15585093
DOI: 10.1089/aid.2004.20.1032

Abstract

The molecular characterization of HIV-1 isolates in drug-naive cases in the early stages of HIV disease was studied in 128 cases from Mumbai (Bombay), India. Subtype C was largely predominant followed by A-C intersubtype recombinants, one subtype A and one CRF01 AE. Compared to subtype B, subtype C exhibited an important polymorphism; the percentages of substitutions could reach more than 90%. Two isolates showed M184V substitution the reverse transcriptase indicating resistance to 3TC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anti-HIV Agents / therapeutic use
Drug Resistance, Viral / genetics*
HIV Infections / drug therapy*
HIV Infections / virology
HIV Protease / genetics
HIV Reverse Transcriptase / genetics
HIV-1 / classification*
HIV-1 / enzymology
HIV-1 / genetics
Humans
India
Molecular Sequence Data
Mutation*
Sequence Analysis, DNA

Substances

Anti-HIV Agents
HIV Reverse Transcriptase
HIV Protease

Associated data

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