Two distinct STLV-1 subtypes infecting Mandrillus sphinx follow the geographic distribution of their hosts

AIDS Res Hum Retroviruses. 2004 Oct;20(10):1137-43. doi: 10.1089/aid.2004.20.1137.

Abstract

The mandrill (Mandrillus sphinx) has been shown to be infected with an STLV-1 closely related to HTLV-1. Two distinct STLV-1 subtypes (D and F) infect wild mandrills with high overall prevalence (27.0%) but are different with respect to their phylogenetic relationship and parallel to the mandrills' geographic range. The clustering of these new STLV-1mnd sequences with HTLV-1 subtype D and F suggests first, past simian-to-human transmissions in Central Africa and second, that species barriers are easier to cross over than geographic barriers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Deltaretrovirus Infections / veterinary*
  • Deltaretrovirus Infections / virology
  • Female
  • Gabon
  • Gene Products, tax / chemistry
  • Gene Products, tax / genetics
  • Male
  • Mandrillus / physiology
  • Mandrillus / virology*
  • Molecular Sequence Data
  • Monkey Diseases / virology*
  • Phylogeny
  • Sequence Analysis, DNA
  • Simian T-lymphotropic virus 1 / classification*
  • Simian T-lymphotropic virus 1 / genetics
  • Simian T-lymphotropic virus 1 / pathogenicity

Substances

  • Gene Products, tax

Associated data

  • GENBANK/AJ564757
  • GENBANK/AJ564758
  • GENBANK/AJ564759
  • GENBANK/AJ564760
  • GENBANK/AJ564761
  • GENBANK/AJ564762
  • GENBANK/AJ564763
  • GENBANK/AJ564764
  • GENBANK/AJ564765