Abstract
PD-1 is a receptor inducibly expressed on CD4+ and CD8+ T cells following activation. PD-1-deficient mice develop signs of autoimmunity, suggesting a negative regulatory role for PD-1 in dampening lymphocyte responses. The expression of one ligand for PD-1, designated PD-L1 or B7-H1, on tumor cells of a variety of histologies has suggested a potential mechanism for tumor escape from immune destruction. This review summarizes data regarding PD-1 and related negative regulatory receptors, focusing on implications for potentiating antitumor immunity in vivo.
MeSH terms
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Animals
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Antigens, CD
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Antigens, Surface / chemistry
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Antigens, Surface / genetics
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Antigens, Surface / immunology*
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Apoptosis Regulatory Proteins
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Autoimmunity / immunology
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B7-1 Antigen / genetics
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B7-1 Antigen / immunology
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B7-H1 Antigen
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Gene Expression / immunology
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Humans
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Immune Tolerance / immunology*
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Intercellular Signaling Peptides and Proteins
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / immunology
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Mice
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Models, Immunological
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Neoplasms / immunology
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Peptides / genetics
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Peptides / immunology
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Programmed Cell Death 1 Ligand 2 Protein
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Programmed Cell Death 1 Receptor
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Receptors, Immunologic / chemistry
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Receptors, Immunologic / genetics
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Receptors, Immunologic / immunology
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T-Lymphocytes / immunology*
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Transplantation Immunology / immunology
Substances
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Antigens, CD
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Antigens, Surface
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Apoptosis Regulatory Proteins
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B7-1 Antigen
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B7-H1 Antigen
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CD274 protein, human
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Cd274 protein, mouse
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Intercellular Signaling Peptides and Proteins
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Membrane Glycoproteins
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PDCD1 protein, human
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PDCD1LG2 protein, human
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Pdcd1 protein, mouse
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Pdcd1lg2 protein, mouse
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Peptides
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Programmed Cell Death 1 Ligand 2 Protein
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Programmed Cell Death 1 Receptor
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Receptors, Immunologic