Results of a phase I study to dose escalate using intensity modulated radiotherapy guided by combined PET/CT imaging with induction chemotherapy for patients with non-small cell lung cancer

Caroline L Holloway; Don Robinson; Brad Murray; John Amanie; Charles Butts; Michael Smylie; Karen Chu; A J McEwan; Ross Halperin; Wilson H Roa

doi:10.1016/j.radonc.2004.07.033

Results of a phase I study to dose escalate using intensity modulated radiotherapy guided by combined PET/CT imaging with induction chemotherapy for patients with non-small cell lung cancer

Radiother Oncol. 2004 Dec;73(3):285-7. doi: 10.1016/j.radonc.2004.07.033.

Authors

Caroline L Holloway¹, Don Robinson, Brad Murray, John Amanie, Charles Butts, Michael Smylie, Karen Chu, A J McEwan, Ross Halperin, Wilson H Roa

Affiliation

¹ Department of Radiation Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alta., Canada T6G 1Z2.

PMID: 15588872
DOI: 10.1016/j.radonc.2004.07.033

Abstract

Intensity modulated radiation therapy (IMRT) guided by PET/CT imaging with respiratory gating was employed to dose escalate in patients with non-small cell lung cancer (NSCLC), using accelerated fractionation with induction chemotherapies. One patient developed a grade 5 pneumonitis and the study was halted at 84 Gy in 35 fractions.

Publication types

Clinical Trial
Clinical Trial, Phase I
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Carcinoma, Non-Small-Cell Lung / pathology
Carcinoma, Non-Small-Cell Lung / radiotherapy*
Dose Fractionation, Radiation
Dose-Response Relationship, Radiation
Female
Humans
Lung Neoplasms / pathology
Lung Neoplasms / radiotherapy*
Male
Middle Aged
Positron-Emission Tomography*
Radiation Pneumonitis
Tomography, X-Ray Computed