Abstract
The aim of this study was to investigate serum levels of IL-2, IL-6 and IL-10 in the pretreatment period and to determine if high IL-2, IL-6, IL-10 levels correlate with the outcome in patients with Non-Hodgkin's Lymphoma (NHL) in the post treatment period. Forty-three patients with the diagnosis of aggressive NHL were included in our study. In all cases initial treatment consisted of CHOP. Patients who failed initial therapy and relapsed from CR were treated with the ESHAP regimen or autologous bone marrow transplantation. The median follow-up duration was 127 weeks (20-228 weeks). There was a negative relationship between the failure-free survival and IL-2 levels (p<0.01). IL-2 levels were negatively correlated with overall survival (p<0.02). There was no relationship between the failure-free survival and IL-6 and IL-10 levels. IL-6 and IL-10 levels did not affect overall survival. In conclusion, in patients with lymphoma, the immune system tries to control the progression of tumor thus leading to high IL-2 levels.
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cisplatin / administration & dosage
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Cyclophosphamide / administration & dosage
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Cytarabine / administration & dosage
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Disease Progression
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Disease-Free Survival
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Doxorubicin / administration & dosage
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Enzyme-Linked Immunosorbent Assay
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Etoposide / administration & dosage
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Female
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Follow-Up Studies
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Humans
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Interleukin-10 / blood*
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Interleukin-2 / blood*
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Interleukin-6 / blood*
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Lymphoma / drug therapy
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Lymphoma, Non-Hodgkin / blood*
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Lymphoma, Non-Hodgkin / diagnosis*
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Lymphoma, Non-Hodgkin / mortality
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Male
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Methylprednisolone / administration & dosage
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Middle Aged
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Prednisone / administration & dosage
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Prognosis
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Regression Analysis
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Time Factors
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Treatment Outcome
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Vincristine / administration & dosage
Substances
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Interleukin-2
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Interleukin-6
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Cytarabine
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Interleukin-10
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Vincristine
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Etoposide
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Doxorubicin
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Cyclophosphamide
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Cisplatin
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Prednisone
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Methylprednisolone
Supplementary concepts
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CHOP protocol
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ESAP protocol