Abstract
Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, Surface / metabolism*
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Antigens, Surface / physiology
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Carrier Proteins / metabolism*
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Carrier Proteins / physiology
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Endotoxins / metabolism
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Lipopolysaccharides / pharmacology
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Lymphocyte Antigen 96
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Membrane Glycoproteins / metabolism*
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Membrane Glycoproteins / physiology
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Receptors, Cell Surface / metabolism*
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Receptors, Cell Surface / physiology
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Signal Transduction / physiology*
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Toll-Like Receptor 4
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Toll-Like Receptors
Substances
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Antigens, Surface
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Carrier Proteins
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Endotoxins
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Lipopolysaccharides
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Lymphocyte Antigen 96
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Membrane Glycoproteins
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Receptors, Cell Surface
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Toll-Like Receptor 4
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Toll-Like Receptors