We report a case of rhabdomyolysis secondary to diabetic hyperosmolar nonketotic coma leading to acute renal failure. The patient had no overt muscle pain or swelling. Urinary myoglobin was negative. The patient was managed with continuous veno-venous hemodiafiltration (CVVHD) and his renal function subsequently recovered. The clinical features of five other reported cases of rhabdomyolysis caused by diabetic hyperosmolar nonketotic coma in the literature are reviewed.