Abstract
A novel trimethoprim resistance gene, designated dfrA20, was detected on the 11-kb plasmid pCCK154 from Pasteurella multocida. The dfrA20 gene codes for a dihydrofolate reductase of 169 amino acids. Sequence comparisons revealed that the DfrA20 protein differed distinctly from all dihydrofolate reductases known so far.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology
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Base Sequence
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Cattle
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Pasteurella multocida / drug effects*
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Pasteurella multocida / enzymology
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Pasteurella multocida / genetics*
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Phylogeny
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Plasmids
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Tetrahydrofolate Dehydrogenase / chemistry
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Tetrahydrofolate Dehydrogenase / genetics*
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Trimethoprim / pharmacology
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Trimethoprim Resistance / genetics*
Substances
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Anti-Bacterial Agents
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Trimethoprim
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Tetrahydrofolate Dehydrogenase