Abstract
The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adhesins, Escherichia coli / physiology*
-
Animals
-
Chronic Disease
-
Escherichia coli Infections / prevention & control*
-
Escherichia coli Proteins / immunology*
-
Female
-
Fimbriae Proteins / immunology*
-
Mice
-
Mice, Inbred C3H
-
Urinary Tract Infections / prevention & control*
-
Vaccination
Substances
-
Adhesins, Escherichia coli
-
Escherichia coli Proteins
-
Fimbriae Proteins