Abstract
A new phenyldihydronaphthalene-type lignan, vitedoin A (1), a new phenylnaphthalene-type lignan alkaloid, vitedoamine A (2), and a new trinorlabdane-type diterpene, vitedoin B (3), were isolated from the seeds of Vitex negundo along with five known lignan derivatives (4-8). Their chemical structures were determined mainly on the basis of NMR and MS data. Compounds 1, 2, and 4-7 showed stronger antioxidative activity than alpha-tocopherol using the ferric thiocyanate method. Compounds 1, 2, and 4-7 showed higher radical-scavenging effect on the stable free radical, 1,1-diphenyl-2-picrylhydrazyl, than L-cysteine.
MeSH terms
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology
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Biphenyl Compounds
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Cysteine / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Molecular Structure
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Picrates / pharmacology
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Plants, Medicinal / chemistry*
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Seeds / chemistry
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Vitex / chemistry*
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alpha-Tocopherol / pharmacology
Substances
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Antioxidants
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Biphenyl Compounds
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Diterpenes
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Drugs, Chinese Herbal
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Lignans
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Naphthalenes
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Picrates
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vitedoamine A
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vitedoin A
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vitedoin B
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1,1-diphenyl-2-picrylhydrazyl
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alpha-Tocopherol
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Cysteine