Dissociation in circadian rhythms in a pseudohypersomnia form of fatal familial insomnia

Neurology. 2004 Dec 28;63(12):2416-8. doi: 10.1212/01.wnl.0000147337.07987.ec.

Abstract

The authors present clinical, sleep, and neuroendocrine features of a patient with genetically confirmed fatal familial insomnia (D178N mutation with heterozygosity at codon 129 of the prion protein gene). The patient exhibited pseudohypersomnia behavior instead of insomnia. There was profound alteration in the sleep-wake cycle with a clear dissociation in the disappearance of circadian and neuroendocrine rhythms, findings unrelated to abnormalities in the hypocretinergic system.

Publication types

  • Case Reports

MeSH terms

  • Adrenocorticotropic Hormone / blood
  • Adult
  • Amyloid / genetics
  • Circadian Rhythm*
  • Codon / genetics
  • Heterozygote
  • Humans
  • Hydrocortisone / blood
  • Insomnia, Fatal Familial / genetics
  • Insomnia, Fatal Familial / metabolism
  • Insomnia, Fatal Familial / physiopathology*
  • Intracellular Signaling Peptides and Proteins / cerebrospinal fluid
  • Male
  • Motor Activity
  • Neuropeptides / cerebrospinal fluid
  • Norepinephrine / blood
  • Orexins
  • Polysomnography
  • Prion Proteins
  • Prions
  • Protein Precursors / genetics

Substances

  • Amyloid
  • Codon
  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Orexins
  • PRNP protein, human
  • Prion Proteins
  • Prions
  • Protein Precursors
  • Adrenocorticotropic Hormone
  • Hydrocortisone
  • Norepinephrine