Aim: To observe the positive rate and its clinical significance of serum antibody to ribosomal P protein (anti-P) in patients with systemic lupus erythematosus (SLE).
Methods: Anti-P protein antibody was detected by EURO blot with synthetic full-length ribosomal proteins, and then correlation between anti-P antibody, other autoantibodies and clinical characters was analysed .
Results: In 150 SLE patients 36 cases (24%) were positive for anti-P antibody. The incidence of renal and central nervous system lesions in anti-P antibody-positive patients was notably higher than that in anti-P antibody-negative group. The positive rate of anti-P antibody was correlated with that of anti-dsDNA, anti-Sm and anti-RNP antibodies, but had no correlation with the lesions of skin, joint, blood and liver, nor indexes of disease's activity (DAI).
Conclusion: There is correlation between anti-P antibody level with renal and CNS lesions in SLE patients.