Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties

Alberto Bianco; Johan Hoebeke; Sylvie Godefroy; Olivier Chaloin; Davide Pantarotto; Jean-Paul Briand; Sylviane Muller; Maurizio Prato; Charalambos D Partidos

doi:10.1021/ja044293y

Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties

J Am Chem Soc. 2005 Jan 12;127(1):58-9. doi: 10.1021/ja044293y.

Authors

Alberto Bianco¹, Johan Hoebeke, Sylvie Godefroy, Olivier Chaloin, Davide Pantarotto, Jean-Paul Briand, Sylviane Muller, Maurizio Prato, Charalambos D Partidos

Affiliation

¹ Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France. [email protected]

PMID: 15631447
DOI: 10.1021/ja044293y

Abstract

Functionalized cationic carbon nanotubes are able to form a stable complex with CpG ODN based on charge interaction and to increase the immunostimulatory activity of CpG motifs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic / administration & dosage*
Adjuvants, Immunologic / chemistry*
Animals
Cations
CpG Islands / immunology*
Interferon-gamma / metabolism*
Interleukin-6 / metabolism
Kinetics
Lymphocytes / drug effects
Lymphocytes / immunology
Mice
Nanotubes, Carbon / chemistry*
Oligonucleotides / administration & dosage
Oligonucleotides / chemistry*
Oligonucleotides / immunology*
Surface Plasmon Resonance

Substances

Adjuvants, Immunologic
Cations
Interleukin-6
Nanotubes, Carbon
Oligonucleotides
Interferon-gamma