Abstract
Serum IgG in a patient with chronic polyneuropathy after Mycoplasma pneumoniae infection reacted with ganglioside GM1, GD1b and asialo-GM1 on thin-layer chromatograms using an immunostaining technique as well as an enzyme-linked immunosorbent assay, suggesting that the galactosyl (beta 1-3)N-acetylgalactosaminyl moiety could be a target antigen in this patient. Serum IgG reacting with these glycolipids may be involved in the pathogenesis of both motor and sensory neuropathies in this patient.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Autoantibodies / analysis*
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Autoimmune Diseases / immunology*
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Child
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Chronic Disease
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Enzyme-Linked Immunosorbent Assay
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Female
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G(M1) Ganglioside / immunology*
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Gangliosides / immunology*
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Humans
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Immunoglobulin G / analysis*
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Male
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Middle Aged
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Neurologic Examination
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Pneumonia, Mycoplasma / immunology*
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Polyradiculoneuropathy / diagnosis
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Polyradiculoneuropathy / immunology*
Substances
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Autoantibodies
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Gangliosides
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Immunoglobulin G
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ganglioside, GD1b
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G(M1) Ganglioside
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asialo GM1 ganglioside