Abietane diterpenes from the cones of Cedrus atlantica

Phytochemistry. 2005 Jan;66(1):105-11. doi: 10.1016/j.phytochem.2004.10.017.

Abstract

Five new abietanes, three of them isolated as the corresponding acetate derivatives, i.e., 9alpha,13alpha-epidioxiabiet-8(14)-en-18-ol, 7alpha,18-diacetoxy, 9beta,13beta-epidioxiabiet-8(14)-ene, 7alpha,18-diacetoxyabiet-8(14)-en-13beta-ol, 7alpha,18-diacetoxy-13beta-methoxyabiet-8(14)-ene, and 13beta-hydroxyabiet-8(14)-en-7-one, were isolated from the neutral part of the hexane extract of the cones of Cedrus atlantica collected in Middle Atlas, Morocco. The structures of these compounds were established by spectroscopic techniques, including 2D NMR spectra, and in the case of 1, by chemical correlation. The cytotoxicity of these abietane diterpenoids was tested against five cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / chemistry*
  • Abietanes / isolation & purification
  • Abietanes / pharmacology
  • Animals
  • Cedrus / chemistry*
  • Cell Line
  • Cell Proliferation / drug effects
  • Molecular Structure
  • Plant Components, Aerial / chemistry

Substances

  • Abietanes