Abstract
This study was designed to explore the possibility that caloric restriction (CR) may benefit Alzheimer's disease (AD) by preventing beta-amyloid (Abeta) neuropathology pivotal to the initiation and progression of the disease. We report that a CR dietary regimen prevents Abeta peptides generation and neuritic plaque deposition in the brain of a mouse model of AD neuropathology through mechanisms associated with promotion of anti-amyloidogenic alpha-secretase activity. Study findings support existing epidemiological evidence indicating that caloric intake may influence risk for AD and raises the possibility that CR may be used in preventative measures aimed at delaying the onset of AD amyloid neuropathology.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adipose Tissue
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Alzheimer Disease / metabolism
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Alzheimer Disease / pathology*
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Alzheimer Disease / prevention & control
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Amyloid Precursor Protein Secretases
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Amyloid beta-Peptides / analysis
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Amyloid beta-Peptides / metabolism*
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Animals
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Aspartic Acid Endopeptidases
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Brain / pathology*
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Brain Chemistry
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Caloric Restriction*
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Diet, Carbohydrate-Restricted*
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Disease Models, Animal*
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Endopeptidases / metabolism
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Female
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Glucose Tolerance Test
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Mice
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Organ Size
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Plaque, Amyloid / metabolism
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Plaque, Amyloid / pathology
Substances
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Amyloid beta-Peptides
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Amyloid Precursor Protein Secretases
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Endopeptidases
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Aspartic Acid Endopeptidases
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Bace1 protein, mouse