Abstract
A DNA variant, rs734232, altering a RUNX1 binding site was recently reported as susceptibility allele at PSORS2 (17q25) in cohorts of psoriasis patients from the US. A testing of this variant in psoriasis patients from Germany did not confirm this association in 300 trios nor in two case-control studies with 281 patients with psoriasis vulgaris and 375 patients with psoriatic arthritis, respectively. These results fail to support rs734232 as a psoriasis susceptibility factor in German psoriasis patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Arthritis, Psoriatic / epidemiology
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Arthritis, Psoriatic / genetics*
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Binding Sites / genetics
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Case-Control Studies
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Chromosomes, Human, Pair 17*
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Chromosomes, Human, Pair 6
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Cohort Studies
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Core Binding Factor Alpha 2 Subunit
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DNA-Binding Proteins / genetics*
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Gene Frequency
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Germany / epidemiology
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Haplotypes
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Humans
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Middle Aged
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Proto-Oncogene Proteins / genetics*
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Psoriasis / epidemiology
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Psoriasis / genetics*
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Risk Factors
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Transcription Factors / genetics*
Substances
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Core Binding Factor Alpha 2 Subunit
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DNA-Binding Proteins
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Proto-Oncogene Proteins
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RUNX1 protein, human
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Transcription Factors