Abstract
Novel 6-substituted thiazolocarbazole derivatives have been synthesized under microwave irradiation via the corresponding imino-1,2,3-dithiazoles. In vitro antitumor potential of these polyheterocyclic compounds was evaluated. Among all the tested thiazolocarbazoles, compound 10 is the most effective in inhibiting cell growth.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents* / chemical synthesis
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Antineoplastic Agents* / pharmacology
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Antineoplastic Agents* / radiation effects
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Carbazoles* / chemical synthesis
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Carbazoles* / pharmacology
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Carbazoles* / radiation effects
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Cell Line
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Humans
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In Vitro Techniques
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Microwaves*
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Molecular Structure
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Stereoisomerism
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Structure-Activity Relationship
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Thiazoles* / chemical synthesis
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Thiazoles* / pharmacology
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Thiazoles* / radiation effects
Substances
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Antineoplastic Agents
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Carbazoles
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Thiazoles