Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats

J Nutr. 2005 Feb;135(2):155-9. doi: 10.1093/jn/135.2.155.

Abstract

Tea catechins, (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin gallate (EGCG), have been shown to be epimerized to (-)-catechin (C), (-)-gallocatechin (GC), (-)-catechin gallate (CG), and (-)-gallocatechin gallate (GCG), respectively, during heat treatment. In this study, we examined the effect of tea catechins rich in ECG and EGCG and heat-treated tea catechins rich in CG and GCG on postprandial hypertriacylglycerolemia in rats. Both tea catechins and heat-treated tea catechins suppressed postprandial hypertriacylglycerolemia. Lymphatic recovery of (14)C-trioleoylglycerol in rats cannulated in the thoracic duct was delayed by the administration of tea catechins and heat-treated tea catechins. Tea catechins and heat-treated tea catechins had the same effect on all variables tested. These catechin preparations dose-dependently inhibited the activity of pancreatic lipase in vitro. When purified catechins were used, only those with a galloyl moiety inhibited the activity of pancreatic lipase. These results suggest that catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by slowing down triacylglycerol absorption through the inhibition of pancreatic lipase. Because postprandial hypertriacylglycerolemia is a risk factor for coronary heart disease, our results suggest that catechins with a galloyl moiety may prevent this disease.

MeSH terms

  • Animals
  • Antioxidants / pharmacokinetics*
  • Antioxidants / pharmacology*
  • Biological Transport / drug effects
  • Catechin / analogs & derivatives*
  • Catechin / pharmacokinetics*
  • Catechin / pharmacology*
  • Dietary Fats / metabolism*
  • Hypertriglyceridemia / prevention & control*
  • Lymphatic System / drug effects
  • Lymphatic System / physiology*
  • Male
  • Models, Animal
  • Rats
  • Rats, Wistar
  • Tea*

Substances

  • Antioxidants
  • Dietary Fats
  • Tea
  • Catechin
  • epicatechin gallate
  • epigallocatechin gallate
  • gallocatechol