Abstract
Mouthwash antiseptic cetylpyridinium chloride (CPC) has potent activity against Candida albicans; however, two of five azole-resistant strains showed reduced CPC susceptibility. To further examine the potential for cross-resistance, CPC-resistant mutants were selected in vitro and their fluconazole susceptibility was tested. MICs were unchanged, and trailing growth generally decreased. With CPC-fluconazole combinations, both antagonism and synergism were observed, which can be explained, in part, by CDR1-CDR2 multidrug transporter upregulation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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ATP-Binding Cassette Transporters / biosynthesis
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ATP-Binding Cassette Transporters / genetics
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Anti-Infective Agents, Local / pharmacology*
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Antifungal Agents / pharmacology*
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Candida albicans / drug effects*
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Cetylpyridinium / pharmacology*
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Drug Resistance, Fungal
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Fluconazole / pharmacology*
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Fungal Proteins / biosynthesis
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Fungal Proteins / genetics
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Immunoblotting
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Membrane Transport Proteins / biosynthesis
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Membrane Transport Proteins / genetics
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Microbial Sensitivity Tests
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Mouthwashes / pharmacology*
Substances
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ATP-Binding Cassette Transporters
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Anti-Infective Agents, Local
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Antifungal Agents
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CDR1 protein, Candida albicans
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Fungal Proteins
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Membrane Transport Proteins
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Mouthwashes
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Fluconazole
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Cetylpyridinium