Abstract
The in vivo efficacy of vancomycin and teicoplanin against five Staphylococcus aureus strains with different susceptibilities to them and methicillin was studied. Rabbits were allocated at random to groups for endocarditis induction with one of these five strains and then treated for 2 days with vancomycin or teicoplanin. Each treated group was compared with a control group infected with the same strain. Vancomycin and teicoplanin showed similar activities. Low MICs did not predict better in vivo results.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Aorta / microbiology
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Colony Count, Microbial
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology
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Glycopeptides / pharmacology
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Glycopeptides / therapeutic use*
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Methicillin / therapeutic use
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Microbial Sensitivity Tests
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Penicillins / therapeutic use
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Predictive Value of Tests
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Rabbits
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects
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Teicoplanin / pharmacology
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Teicoplanin / therapeutic use
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Vancomycin / pharmacology
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Vancomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Glycopeptides
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Penicillins
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Teicoplanin
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Vancomycin
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Methicillin