[Concomitant use of radiotherapy and gemcitabine: preclinical findings and clinical practice]

Cancer Radiother. 2004 Nov:8 Suppl 1:S106-13.
[Article in French]

Abstract

Gemcitabine is pyrimidine analog which has demonstrated antitumoral activity in a variety of solid tumors. Laboratory studies demonstrating that gemcitabine is a potent radiosensitizer led to a variety of trials combining radiation and gemcitabine. In the clinic, phase I-II studies are still trying to determine the optimal dose and schedule which could be use in daily clinical practice. This review summarizes the mechanisms of interaction between radiotherapy and gemcitabine and presents several therapeutic schemes for each tumor location.

Publication types

  • Comparative Study
  • English Abstract
  • Review

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / radiotherapy
  • Animals
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / pharmacology
  • Antimetabolites, Antineoplastic / therapeutic use*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / radiotherapy
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Carcinoma, Non-Small-Cell Lung / radiotherapy
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / radiotherapy
  • Clinical Trials, Phase I as Topic
  • Clinical Trials, Phase II as Topic
  • Combined Modality Therapy
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / pharmacology
  • Deoxycytidine / therapeutic use*
  • Female
  • Gemcitabine
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / radiotherapy
  • Male
  • Mice
  • Neoplasms / drug therapy*
  • Neoplasms / radiotherapy*
  • Otorhinolaryngologic Neoplasms / drug therapy
  • Otorhinolaryngologic Neoplasms / radiotherapy
  • Pancreatic Neoplasms / drug therapy
  • Pancreatic Neoplasms / radiotherapy
  • Radiation-Sensitizing Agents / administration & dosage
  • Radiation-Sensitizing Agents / pharmacology
  • Radiation-Sensitizing Agents / therapeutic use*
  • Radiotherapy Dosage
  • Randomized Controlled Trials as Topic
  • Rats
  • Time Factors
  • Tumor Cells, Cultured / drug effects
  • Urinary Bladder Neoplasms / drug therapy
  • Urinary Bladder Neoplasms / radiotherapy
  • Uterine Cervical Neoplasms / drug therapy
  • Uterine Cervical Neoplasms / radiotherapy

Substances

  • Antimetabolites, Antineoplastic
  • Radiation-Sensitizing Agents
  • Deoxycytidine
  • Gemcitabine