Abstract
Recently, proteolipid protein 1 (PLP1) has been identified as downregulated in schizophrenia by quantitative PCR and other technologies. In this work we attempted to investigate the role of PLP1 in the etiology of schizophrenia using a family based association study in 487 Chinese Han family trios. The TDT for allelic association demonstrated that, in male, a weak association was detected in SNP rs475827 with p=0.0294, suggesting that the genetic polymorphisms within PLP1 in male are likely to confer an increased susceptibility to schizophrenia in the Chinese population.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Asian People / ethnology
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Chi-Square Distribution
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Family Health*
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Female
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Gene Frequency
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Genetic Predisposition to Disease*
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Genotype
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Humans
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Linkage Disequilibrium
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Male
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Membrane Proteins / genetics*
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Myelin Proteolipid Protein / genetics*
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Polymorphism, Single Nucleotide / genetics*
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RNA, Messenger / metabolism
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Reverse Transcriptase Polymerase Chain Reaction / methods
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Schizophrenia / genetics*
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Sex Factors
Substances
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Membrane Proteins
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Myelin Proteolipid Protein
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PLP1 protein, human
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RNA, Messenger