Abstract
The mGluR5 antagonist MPEP was used to study the role of mGluR5 in MPTP-induced injury of the nigrostriatal DA neurons. The findings indicate that acute blockade of mGluR5 may result in neuroprotective actions against MPTP neurotoxicity on nigral DA cell bodies and striatal DA terminals using stereological analysis of TH immunoreactivity and microdensitometry. Biochemical analysis showed no restoration of DA levels and metabolism indicating a maintained reduction of DA transmission.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Proliferation / drug effects
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism
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Dopamine / metabolism*
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MPTP Poisoning / metabolism
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MPTP Poisoning / prevention & control*
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Male
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Mice
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Mice, Inbred C57BL
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Neurons / drug effects
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Neurons / metabolism
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Presynaptic Terminals / drug effects*
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Presynaptic Terminals / metabolism
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Pyridines / administration & dosage*
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate / antagonists & inhibitors*
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Receptors, Metabotropic Glutamate / metabolism
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Substantia Nigra / drug effects*
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Substantia Nigra / metabolism
Substances
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GRM5 protein, human
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Grm5 protein, mouse
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Pyridines
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate
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6-methyl-2-(phenylethynyl)pyridine
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Dopamine