Abstract
The effect of treatment with steroid-eluting stents on systemic inflammatory response was investigated in patients with unstable angina pectoris or recent myocardial infarction who underwent percutaneous intervention. Compared with controls, dexamethasone-eluting stents significantly reduced C-reactive protein peak levels 48 hours after the procedure; this effect persisted for 7 days and was particularly evident in patients with elevated (>/=3 mg/L) preprocedural C-reactive protein values. Patients receiving a dexamethasone-eluting stent had lower adverse events during follow-up.
MeSH terms
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Angina Pectoris / blood
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Angina Pectoris / mortality
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Angina Pectoris / therapy
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Angioplasty, Balloon, Coronary
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Anti-Inflammatory Agents / administration & dosage*
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Biomarkers / blood
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C-Reactive Protein / analysis*
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Case-Control Studies
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Coronary Artery Disease / blood
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Coronary Artery Disease / mortality
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Coronary Artery Disease / therapy
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Dexamethasone / administration & dosage*
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Female
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Humans
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Male
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Middle Aged
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Myocardial Infarction / blood
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Myocardial Infarction / mortality
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Myocardial Infarction / therapy
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Prospective Studies
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Stents*
Substances
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Anti-Inflammatory Agents
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Biomarkers
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Dexamethasone
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C-Reactive Protein