Abstract
Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacteremia / microbiology
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Bacteremia / mortality*
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Child, Preschool
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Enterobacteriaceae / enzymology*
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Enterobacteriaceae / pathogenicity
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Enterobacteriaceae Infections / microbiology
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Enterobacteriaceae Infections / mortality*
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Escherichia coli / enzymology
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Escherichia coli / pathogenicity
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Female
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Humans
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Infant
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Infant, Newborn
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / pathogenicity
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Male
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Salmonella enterica / classification
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Salmonella enterica / enzymology
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Salmonella enterica / pathogenicity
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Tanzania / epidemiology
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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beta-lactamase SHV-12
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beta-Lactamases