Abstract
We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.
Publication types
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Comparative Study
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Evaluation Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adaptation, Physiological / genetics
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Algorithms*
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Animals
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Computer Simulation
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Genes, Regulator / physiology*
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Humans
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Models, Genetic*
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Signal Transduction / physiology*
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Transcription Factors / physiology*
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Transcriptional Activation / physiology*