Resective surgery to treat refractory status epilepticus in children with focal epileptogenesis

Neurology. 2005 Feb 8;64(3):567-70. doi: 10.1212/01.WNL.0000150580.40019.63.

Abstract

Prolonged high-dose suppressive therapy (HDST) is a mainstay in the management of refractory status epilepticus (RSE), albeit with high morbidity and mortality. The authors studied 10 patients who were carefully selected for epilepsy surgery after failing prolonged (>2 weeks) HDST. Status epilepticus was stopped acutely in all of them with no mortality and no substantial morbidity. At follow-up (median 7 months), 7 (70%) of 10 patients were seizure free, and 3 (30%) of 10 had significant improvement in their epilepsy.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Anticonvulsants / therapeutic use
  • Brain / abnormalities
  • Child
  • Combined Modality Therapy
  • Encephalitis / complications
  • Epilepsies, Partial / drug therapy
  • Epilepsies, Partial / etiology
  • Epilepsies, Partial / surgery*
  • Female
  • Follow-Up Studies
  • Hemianopsia / epidemiology
  • Hemispherectomy
  • Humans
  • Infant
  • Infarction, Middle Cerebral Artery / complications
  • Male
  • Paresis / etiology
  • Postoperative Complications
  • Retrospective Studies
  • Status Epilepticus / etiology
  • Status Epilepticus / surgery*
  • Treatment Outcome
  • Tuberous Sclerosis / complications

Substances

  • Anticonvulsants