Expeditious synthesis of enantiopure symmetrical macroheterocycles by ring-closing metathesis of ether and tether-linked 1,2-O-isopropylidenefuranosides

Carbohydr Res. 2005 Mar 21;340(4):567-78. doi: 10.1016/j.carres.2004.12.024.

Abstract

Bis-olefinic symmetrical carbohydrate derivatives were prepared by joining two 1,2-O-isopropylidenefuranose units either through an ether linkage or by a tether of variable size. The ring-closing metathesis (RCM) of these substrates using Grubbs' first-generation catalyst led to the synthesis of enantiopure symmetrical macroheterocycles containing nine- to twenty-five-membered rings fused to the 1,2-O-isopropylidenefuranose ring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclization
  • Ethers / chemistry*
  • Heterocyclic Compounds / chemical synthesis*
  • Heterocyclic Compounds / chemistry
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Pentoses / chemistry
  • Stereoisomerism

Substances

  • Ethers
  • Heterocyclic Compounds
  • Pentoses