Ocular melanoma is a rare tumour with a poor prognosis when initial tumour burden is large. In France, the disease incidence is estimated to 7/1,000,000 persons. Except for the presence of an Ota's naevus, no risk factor has been clearly identified. In many patients, radiotherapy offers an alternative local therapy to surgery. No adjuvant treatment has demonstrated any benefit. Treatment of metastatic disease has to be precised.