Abstract
The in vitro activity of the histatin derivative P-113, alone or combined with eight antibiotics, was investigated against multidrug-resistant strains isolated from clinical specimens of immunocompromised patients with pneumonia. The gram-negative isolates were susceptible to P-113. S. aureus showed less susceptibility. Synergy was demonstrated when P-113 was combined with beta-lactams against gram-negative organisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Drug Resistance, Multiple, Bacterial
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Histatins
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Humans
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Immunocompromised Host
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Microbial Sensitivity Tests
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Pneumonia, Bacterial / microbiology*
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Pseudomonas aeruginosa / drug effects*
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Salivary Proteins and Peptides / pharmacology*
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Staphylococcus aureus / drug effects*
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Stenotrophomonas maltophilia / drug effects*
Substances
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Histatins
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P-113D
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Salivary Proteins and Peptides