(-)-Echinobetaine A: isolation, structure elucidation, synthesis, and SAR studies on a new nematocide from a southern Australian marine sponge, Echinodictyum sp

Robert J Capon; Dat Vuong; Ernest Lacey; Jennifer H Gill

doi:10.1021/np049687h

(-)-Echinobetaine A: isolation, structure elucidation, synthesis, and SAR studies on a new nematocide from a southern Australian marine sponge, Echinodictyum sp

J Nat Prod. 2005 Feb;68(2):179-82. doi: 10.1021/np049687h.

Authors

Robert J Capon¹, Dat Vuong, Ernest Lacey, Jennifer H Gill

Affiliation

¹ Centre for Molecular Biodiversity, Institute for Molecular Biosciences, University of Queensland, St. Lucia, Queensland 4072, Australia. [email protected]

PMID: 15730239
DOI: 10.1021/np049687h

Abstract

A nematocidal agent present in a southern Australian marine sponge of the genus Echinodictyum has been isolated and identified by detailed spectroscopic analysis and total synthesis as the novel betaine (-)-echinobetaine A (6). Preliminary SAR investigations have been undertaken.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antinematodal Agents / chemistry
Antinematodal Agents / isolation & purification*
Antinematodal Agents / pharmacology
Australia
Betaine / analogs & derivatives*
Betaine / chemistry
Betaine / isolation & purification*
Betaine / pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera / chemistry*
Stereoisomerism
Structure-Activity Relationship

Substances

Antinematodal Agents
echinobetaine A
Betaine