Synthesis of a beta-amino acid pharmacophore via a beta-lactam intermediate

J Org Chem. 2005 Mar 4;70(5):1949-52. doi: 10.1021/jo048249c.

Abstract

A stereoselective synthesis of (R)-beta-amino acid 1 via a beta-lactam intermediate is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acylation
  • Amino Acids / chemical synthesis*
  • Drug Design
  • Molecular Conformation
  • Stereoisomerism
  • Structure-Activity Relationship
  • beta-Lactams / chemical synthesis
  • beta-Lactams / chemistry*

Substances

  • Amino Acids
  • beta-Lactams