Abstract
Nasal carriage is a major risk factor for Staphylococcus aureus infection, especially for methicillin-resistant strains (MRSA). Using a mouse model of nasal carriage, we have compared several S. aureus strains and demonstrated increased colonization levels by MRSA in cystic fibrosis transmembrane conductance regulator-deficient mice and Toll-like receptor 2 (TLR2)-deficient mice but not TLR4-deficient mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carrier State / microbiology*
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Colony Count, Microbial
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Female
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Humans
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Methicillin Resistance*
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Inbred CFTR
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Mice, Knockout
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Nose / microbiology*
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Receptors, Cell Surface / genetics
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Staphylococcal Infections / microbiology*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / isolation & purification*
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Toll-Like Receptor 2
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Toll-Like Receptor 4
Substances
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Receptors, Cell Surface
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Tlr2 protein, mouse
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Tlr4 protein, mouse
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Toll-Like Receptor 2
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Toll-Like Receptor 4