Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs

Infect Immun. 2005 Mar;73(3):1873-8. doi: 10.1128/IAI.73.3.1873-1878.2005.

Abstract

Sublethal infection of C57BL/6 mice with Salmonella enterica serovar Typhimurium M525P initiates a strong inflammatory response. We measured organ expression of mRNA for Toll-like receptors and their associated signaling molecules during S. enterica serovar Typhimurium infection. During infection, the Toll-lie receptor 1 (TLR1), TLR2, and TLR9 mRNA levels increased, while TLR6 mRNA expression decreased.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism
  • Down-Regulation
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / metabolism*
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Organ Specificity
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Salmonella Infections, Animal / microbiology
  • Salmonella Infections, Animal / physiopathology*
  • Salmonella typhimurium / pathogenicity*
  • Toll-Like Receptor 1
  • Toll-Like Receptor 2
  • Toll-Like Receptor 6
  • Toll-Like Receptor 9
  • Toll-Like Receptors
  • Up-Regulation

Substances

  • DNA-Binding Proteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Tlr2 protein, mouse
  • Tlr6 protein, mouse
  • Tlr9 protein, mouse
  • Toll-Like Receptor 1
  • Toll-Like Receptor 2
  • Toll-Like Receptor 6
  • Toll-Like Receptor 9
  • Toll-Like Receptors