Abstract
Consumption of a naturally occurring polyphenol, resveratrol, in particular through drinking moderate amounts of red wine, has been suggested to be beneficial to health. A plethora of in vitro studies published demonstrate various anti-inflammatory actions of resveratrol. The aim of this research was to determine whether any of these anti-inflammatory effects translate in vivo in a rodent model of LPS induced airway inflammation. Resveratrol reduced lung tissue neutrophilia to a similar magnitude as that achieved by treatment with budesonide. This was associated with a reduction in pro-inflammatory cytokines and prostanoid levels. Interestingly, the reduction did not appear to be due to an impact on NF-kappaB activation or the expression of the respective genes as suggested by various in vitro publications. These results suggest that resveratrol may possess anti-inflammatory properties via a novel mechanism. Elucidation of this mechanism may lead to potential new therapies for the treatment of chronic inflammation.
MeSH terms
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Animals
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Budesonide / administration & dosage
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Cytokines / genetics
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DNA / metabolism
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Dinoprostone / analysis
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Gene Expression / drug effects
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Inflammation / metabolism
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Inflammation / pathology
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Inflammation / prevention & control*
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Inflammation Mediators / metabolism*
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Lipopolysaccharides
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Lung / drug effects
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Lung / metabolism*
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Lung / pathology
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Male
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NF-kappa B / physiology
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Neutrophils / enzymology
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Neutrophils / pathology*
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Nitric Oxide Synthase Type II / genetics
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Peritoneum / drug effects
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Peroxidase / analysis
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Prostaglandin-Endoperoxide Synthases / genetics
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Rats
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Rats, Wistar
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Resveratrol
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Stilbenes / administration & dosage*
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Wine / analysis*
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Cytokines
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Inflammation Mediators
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Lipopolysaccharides
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NF-kappa B
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Stilbenes
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Budesonide
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DNA
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Peroxidase
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Nitric Oxide Synthase Type II
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Prostaglandin-Endoperoxide Synthases
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Dinoprostone
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Resveratrol