Abstract
Gene expression, differentiation and the specialized function of various cell types are controlled epigenetically by post-translational histone modifications. These modifications establish a "histone code" that is recognized by various regulatory proteins, thereby creating a stable pattern of gene expression. The focus of this review is to discuss how the chromatin modifications regulate immunoglobulin gene rearrangement and B cell differentiation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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B-Lymphocytes / immunology*
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Cell Differentiation / genetics
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Chromatin / metabolism
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Epigenesis, Genetic*
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Humans
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Immunoglobulins / genetics
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Lymphopoiesis / genetics*
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Polycomb-Group Proteins
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Protein Processing, Post-Translational
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Recombination, Genetic
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Repressor Proteins
Substances
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Chromatin
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Immunoglobulins
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Polycomb-Group Proteins
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Repressor Proteins