Low frequency of exon 3 PTPN11 mutations in adult de novo acute myeloid leukemia. Analysis of a consecutive series of 173 patients

Josep Nomdedéu; Maria T Carricondo; Adriana Lasa; Granada Perea; Ana Aventin; Jorge Sierra

Low frequency of exon 3 PTPN11 mutations in adult de novo acute myeloid leukemia. Analysis of a consecutive series of 173 patients

Haematologica. 2005 Mar;90(3):412-3.

Authors

Josep Nomdedéu, Maria T Carricondo, Adriana Lasa, Granada Perea, Ana Aventin, Jorge Sierra

PMID: 15749679

Abstract

A total of 173 samples obtained from adult patients with de novo acute myeloid leukemia (AML) were assayed for exon 3 PTPN11 mutations by single strand conformation polymorphism (SSCP) analysis and direct sequencing. Only three monocytic leukemias had point mutations (1.73%).

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Adult
Cause of Death
Exons
Female
Gene Frequency
Humans
Intracellular Signaling Peptides and Proteins / genetics*
Leukemia, Myeloid / genetics*
Male
Middle Aged
Point Mutation*
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatases / genetics*
Spain

Substances

Intracellular Signaling Peptides and Proteins
PTPN11 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatases