Abstract
The incidence of norovirus-associated gastroenteritis and the molecular epidemiology of norovirus strains were studied during three seasons (2000-2001, 2001-2002, and 2002-2003) among patients of all ages, mainly from the Stockholm region in Sweden. A total of 3,252 fecal samples were analyzed by reverse transcription-PCR. The incidences of norovirus infection among adults were 23, 26, and 30% during the three seasons studied and 18, 11, and 15% among children 0 to 15 years of age. During the first season, all norovirus strains detected by PCR were typed either by reverse line blot hybridization or nucleotide sequence analysis. During the two successive seasons, a total of 60 norovirus-positive strains from the beginning, peak, and end of the seasons were selected for nucleotide sequence analysis. We identified two dominant norovirus variants over the seasons: a new norovirus variant, recently described as the GGIIb genetic cluster, dominated among children during the first season, and during the following two seasons, a GGII-4 variant dominated. Our data suggest that norovirus infections are common, not only among adults, but also among children, and that some strains may predominantly affect children.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Base Sequence
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Caliciviridae Infections / epidemiology*
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Child
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Child, Preschool
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Disease Outbreaks
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Gastroenteritis / epidemiology*
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Humans
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Incidence
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Infant
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Infant, Newborn
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Molecular Sequence Data
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Norovirus / classification
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Norovirus / genetics
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Norovirus / isolation & purification*
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Seasons
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Sweden / epidemiology
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Time Factors
Associated data
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GENBANK/AJ626557
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GENBANK/AJ626558
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GENBANK/AJ626559
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