Abstract
We describe an outbreak of Pneumocystis jirovecii pneumonia in a pediatric renal transplant unit, likely attributable to patient-to-patient transmission. Single-strand conformation polymorphism molecular typing showed that 3 affected patients had acquired the same 2 strains of Pneumocystis, which suggests interhuman infection. An infant with mitochondriopathy was the probable index patient.
MeSH terms
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Adolescent
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Cross Infection / immunology
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Cross Infection / microbiology*
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Cross Infection / transmission
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DNA, Mitochondrial / chemistry
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DNA, Mitochondrial / genetics
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DNA, Ribosomal Spacer / chemistry
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DNA, Ribosomal Spacer / genetics
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DNA, Viral / chemistry
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DNA, Viral / genetics
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Disease Transmission, Infectious*
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Female
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Humans
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Immunocompromised Host
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Infant
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Kidney Transplantation / adverse effects*
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Kidney Transplantation / immunology
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Male
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Pneumocystis carinii*
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Pneumonia, Pneumocystis / immunology
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Pneumonia, Pneumocystis / transmission*
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Polymerase Chain Reaction
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Polymorphism, Single-Stranded Conformational
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RNA, Ribosomal / chemistry
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RNA, Ribosomal / genetics
Substances
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DNA, Mitochondrial
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DNA, Ribosomal Spacer
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DNA, Viral
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RNA, Ribosomal
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RNA, ribosomal, 26S