Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP

Lu Yang; David E Williams; Alice Mui; Christopher Ong; Gerald Krystal; Rob van Soest; Raymond J Andersen

doi:10.1021/ol047316m

Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP

Org Lett. 2005 Mar 17;7(6):1073-6. doi: 10.1021/ol047316m.

Authors

Lu Yang¹, David E Williams, Alice Mui, Christopher Ong, Gerald Krystal, Rob van Soest, Raymond J Andersen

Affiliation

¹ Department of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, B.C., Canada V6T 1Z1.

PMID: 15760142
DOI: 10.1021/ol047316m

Abstract

[reaction: see text] A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analogues have been synthesized from sclareolide (4).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents / chemical synthesis*
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / pharmacology
Diterpenes / chemistry*
Inositol Polyphosphate 5-Phosphatases
Mice
Models, Animal
Molecular Structure
Phosphoric Monoester Hydrolases / drug effects*
Porifera / chemistry*
Sesquiterpenes / chemical synthesis*
Sesquiterpenes / chemistry
Sesquiterpenes / pharmacology
Stereoisomerism

Substances

Anti-Inflammatory Agents
Diterpenes
Sesquiterpenes
pelorol
sclareolide
Phosphoric Monoester Hydrolases
Inositol Polyphosphate 5-Phosphatases