Abstract
The butanolic fraction of dried leaves of Acacia pennata (Mimosaceae) was tested for analgesic and anti-inflammatory activities in animal models. It showed significant protective effects against chemical stimuli (acetic acid and formalin) in the mouse. It also produced a significant increase of the threshold of sensitivity to pressure-induced pain in the rats. The extract revealed an inhibitory effect in carrageenin-induced rat paw oedema in the late phase. The results suggested that a peripheral mechanism is involved in the analgesic, associated to anti-inflammatory effect (NSAIDs-like). Among the class of compounds characterized in this fraction, flavonoids may be mainly responsible for the pharmacological activities.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetic Acid / administration & dosage
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Acetic Acid / adverse effects
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Administration, Oral
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Analgesics, Non-Narcotic / chemistry
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Analgesics, Non-Narcotic / isolation & purification
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Analgesics, Non-Narcotic / pharmacology*
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Butanols / administration & dosage
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Butanols / chemistry
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Butanols / therapeutic use
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Carrageenan / adverse effects
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical / methods
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Edema / chemically induced
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Edema / prevention & control
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Female
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Formaldehyde / administration & dosage
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Formaldehyde / adverse effects
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Formaldehyde / antagonists & inhibitors
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Hindlimb / physiopathology
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Male
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Mice
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Mimosa / chemistry*
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Pain / drug therapy
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Pain / etiology
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Pain / prevention & control
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Leaves / chemistry
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Pressure / adverse effects
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Rats
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Rats, Wistar
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Stimulation, Chemical
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Tramadol / pharmacology
Substances
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Analgesics, Non-Narcotic
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Anti-Inflammatory Agents, Non-Steroidal
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Butanols
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Flavonoids
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Plant Extracts
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Formaldehyde
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Tramadol
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Carrageenan
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Acetic Acid