Impaired levodopa response in Parkinson's disease during melanoma therapy

Clin Neuropharmacol. 1992 Feb;15(1):69-74. doi: 10.1097/00002826-199202000-00010.

Abstract

A patient with melanoma and sporadic positive melanuria developed Parkinson's disease. Treatment with levodopa failed to modify tumoral progress. However, during chemotherapy with dacarbazine, the patient experienced a significant impairment to levodopa response.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Dacarbazine / adverse effects*
  • Dacarbazine / therapeutic use
  • Dopamine / blood
  • Drug Interactions
  • Humans
  • Levodopa / therapeutic use*
  • Male
  • Melanins / urine
  • Melanoma / complications*
  • Melanoma / drug therapy
  • Parkinson Disease / complications
  • Parkinson Disease / drug therapy*
  • Skin Neoplasms / complications*
  • Skin Neoplasms / drug therapy

Substances

  • Melanins
  • Levodopa
  • Dacarbazine
  • Dopamine