Abstract
Facially amphiphilic urea oligomers were successfully prepared in a one-pot reaction by carbonyl diimidazole (CDI) coupling and showed greater antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Bacillus subtilis than MSI-78.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Bacillus subtilis / drug effects*
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Dimerization
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Escherichia / drug effects*
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Imidazoles / chemistry
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Molecular Structure
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Urea / chemistry*
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Urea / metabolism
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Urea / pharmacology*
Substances
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Anti-Bacterial Agents
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Imidazoles
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N,N-carbonyldiimidazole
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Urea