Abstract
Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.
MeSH terms
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Aldosterone / metabolism*
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Animals
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Epithelial Sodium Channels
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Humans
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Immediate-Early Proteins
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Kidney / metabolism*
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Nuclear Proteins / metabolism*
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Protein Serine-Threonine Kinases / metabolism*
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Sodium / metabolism*
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Sodium Channels / metabolism
Substances
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Epithelial Sodium Channels
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Immediate-Early Proteins
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Nuclear Proteins
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Sodium Channels
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Aldosterone
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Sodium
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Protein Serine-Threonine Kinases
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serum-glucocorticoid regulated kinase