Interferon alfa treatment for Sjogren's syndrome associated neuropathy

S Yamada; K Mori; K Matsuo; A Inukai; Y Kawagashira; G Sobue

doi:10.1136/jnnp.2004.049502

Interferon alfa treatment for Sjogren's syndrome associated neuropathy

J Neurol Neurosurg Psychiatry. 2005 Apr;76(4):576-8. doi: 10.1136/jnnp.2004.049502.

Authors

S Yamada¹, K Mori, K Matsuo, A Inukai, Y Kawagashira, G Sobue

Affiliation

¹ Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466-8550, Japan.

Abstract

Treatment response to interferon alfa (IFNalpha) is described in three consecutive cases of two forms of Sjogren's syndrome associated neuropathy (SSN)-two with sensory ataxic ganglionopathy and one with sensorimotor neuropathy with demyelinating features. All responded well to IFNalpha in terms of neuropathic symptoms, sicca symptoms, antibody titres, and findings in salivary gland biopsy specimens. IFNalpha thus showed promise in treating both SSN and the underlying Sjogren's syndrome.

Publication types

Case Reports

MeSH terms

Aged
Antibodies / immunology
Basal Ganglia / pathology
Biopsy
Demyelinating Diseases / pathology
Enzyme-Linked Immunosorbent Assay
Evoked Potentials, Somatosensory / physiology
Female
Gait Ataxia / etiology*
Gait Ataxia / pathology
Gait Ataxia / physiopathology
Humans
Immunologic Factors / therapeutic use*
Interferon-alpha / therapeutic use*
Male
Middle Aged
Neural Conduction / physiology
Paresthesia / etiology*
Paresthesia / pathology
Paresthesia / physiopathology
Salivary Glands / pathology
Sjogren's Syndrome / complications*
Sjogren's Syndrome / drug therapy*
Sjogren's Syndrome / immunology

Substances

Antibodies
Immunologic Factors
Interferon-alpha