Abstract
We present two patients with demyelinating disease meeting the diagnostic criteria for multiple sclerosis. Both patients had IgG lambda monoclonal gammopathy in serum and cerebrospinal fluid associated with intrathecal antibody synthesis. This association is very unusual and it is not certain whether the co-occurrence of these disorders might be the result of a causal link between multiple sclerosis and monoclonal gammopathy or a fortuitous phenomenon.
MeSH terms
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Antibodies, Monoclonal / blood
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Antibodies, Monoclonal / cerebrospinal fluid
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Antibody Formation
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Brain / pathology
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Humans
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Immunoglobulin G / blood
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Immunoglobulin G / cerebrospinal fluid
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Isoelectric Focusing
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Monoclonal Gammopathy of Undetermined Significance / blood
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Monoclonal Gammopathy of Undetermined Significance / cerebrospinal fluid
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Monoclonal Gammopathy of Undetermined Significance / complications*
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Monoclonal Gammopathy of Undetermined Significance / immunology
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Multiple Sclerosis / complications*
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Multiple Sclerosis / diagnosis
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Oligoclonal Bands / blood
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Oligoclonal Bands / cerebrospinal fluid
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Spinal Cord / immunology
Substances
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Antibodies, Monoclonal
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Immunoglobulin G
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Oligoclonal Bands