Molecular approaches to antithrombotic therapy

Hosp Pract (Off Ed). 1992 May 15;27(5):77-86. doi: 10.1080/21548331.1992.11705417.

Abstract

Several new approaches to direct and indirect inhibition of thrombin formation or activity promise to extend the benefits of pharmacologic antithrombotic interventions, both prophylactically and in acute therapy. Preliminary studies have found the new agents to be more specific and hemostatically safer than warfarin or heparin.

Publication types

  • Review

MeSH terms

  • Amino Acid Chloromethyl Ketones / pharmacology
  • Antithrombins / therapeutic use*
  • Arginine / analogs & derivatives
  • Heparin / pharmacology
  • Hirudins / analogs & derivatives
  • Hirudins / pharmacology
  • Humans
  • Peptide Fragments / pharmacology
  • Pipecolic Acids / pharmacology
  • Protease Inhibitors / pharmacology
  • Sulfonamides
  • Thrombin / antagonists & inhibitors*
  • Thrombin / metabolism
  • Warfarin / pharmacology

Substances

  • Amino Acid Chloromethyl Ketones
  • Antithrombins
  • Hirudins
  • Peptide Fragments
  • Pipecolic Acids
  • Protease Inhibitors
  • Sulfonamides
  • hirugen
  • Warfarin
  • Heparin
  • Arginine
  • Thrombin
  • argatroban
  • phenylalanyl-prolyl-arginine-chloromethyl ketone