A 67-year-old man with a solitary left kidney and baseline serum creatinine of 3.3 ng/mL (normal range 0.7 to 1.4) underwent laparoscopic cryoablation of two enhancing, solid renal tumors. Postoperatively, the case was complicated by a large blood clot in the renal collecting system causing obstruction and anuria. This complication of cryotherapy, never before reported to our knowledge, was treated successfully with a temporary ureteral stent. Follow-up magnetic resonance imaging at 3 months did not demonstrate any new lesions or enhancement of the treated renal masses. His serum creatinine at 3 months was 3.7 ng/mL.