Cellular oscillators: rhythmic gene expression and metabolism

Curr Opin Cell Biol. 2005 Apr;17(2):223-9. doi: 10.1016/j.ceb.2005.01.007.

Abstract

Many biological processes are driven by biological clocks that, depending on the frequency they generate, are classified into ultradian, circadian and infradian oscillators. In virtually all light-sensitive organisms from cyanobacteria to humans, a circadian timing system adapts cyclic physiology to geophysical time. Recent evidence suggests that even in mammals circadian oscillators function in a cell-autonomous manner. In yeast, an ultradian oscillator regulates cyclic respiratory activity and global gene expression. Circadian oscillators and the ultradian yeast respiratory clock share at least four properties: they follow limit-cycle kinetics, interweave with cellular metabolism, are temperature-compensated and influence the cell division clock.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Clocks / physiology*
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Cell Respiration / physiology
  • Circadian Rhythm / physiology*
  • Energy Metabolism / physiology*
  • Gene Expression Regulation / physiology*
  • Humans
  • Temperature
  • Yeasts / genetics
  • Yeasts / metabolism

Substances

  • Cell Cycle Proteins